Drug interactions
Haloperidol + Remimazolam
Severity: Moderate
Haloperidol and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an intravenous benzodiazepine sedative with an antipsychotic can deepen sedation and cause hypotension and respiratory depression. The effect is additive and can be more pronounced in older or frail patients.
What this interaction means in plain words
Haloperidol and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation by remimazolam and dopaminergic, histaminergic and adrenergic blockade by haloperidol.
What to do
Titrate remimazolam carefully to effect, using lower doses if needed. Continuously monitor oxygen saturation, respiration and blood pressure during and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Haloperidol and Remimazolam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Haloperidol with Remimazolam?
MediHelp rates the interaction as moderate. Haloperidol and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an intravenous benzodiazepine sedative with an antipsychotic can deepen sedation and cause hypotension and respiratory depression. The effect is additive and can be more pronounced in older or frail patients.
How serious is the interaction between Haloperidol and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully to effect, using lower doses if needed. Continuously monitor oxygen saturation, respiration and blood pressure during and after the procedure.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
