Drug interactions
Haloperidol + Selumetinib
Severity: Moderate
Haloperidol and Selumetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib is cleared largely by CYP3A4, and haloperidol is a weak to moderate CYP3A4 inhibitor. Coadministration may raise selumetinib exposure and increase its toxicities such as gastrointestinal effects, rash and cardiomyopathy. The effect is probably modest compared with strong inhibitors.
What this interaction means in plain words
Haloperidol and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Selumetinib belongs to Oncology.
Why it happens
Haloperidol inhibits CYP3A4, decreasing the metabolism of selumetinib.
What to do
Monitor for selumetinib adverse effects and consider an alternative antipsychotic that does not inhibit CYP3A4. If a labeled CYP3A4 inhibitor dose reduction is required, follow the selumetinib labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Selumetinib
Frequently asked questions
Can I take Haloperidol with Selumetinib?
MediHelp rates the interaction as moderate. Haloperidol and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selumetinib is cleared largely by CYP3A4, and haloperidol is a weak to moderate CYP3A4 inhibitor. Coadministration may raise selumetinib exposure and increase its toxicities such as gastrointestinal effects, rash and cardiomyopathy. The effect is probably modest compared with strong inhibitors.
How serious is the interaction between Haloperidol and Selumetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for selumetinib adverse effects and consider an alternative antipsychotic that does not inhibit CYP3A4. If a labeled CYP3A4 inhibitor dose reduction is required, follow the selumetinib labeling.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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