Drug interactions
Haloperidol + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Haloperidol and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can have cardiovascular effects including QT prolongation and tachycardia, which may be additive with haloperidol. Systemic exposure from inhalation is low, so the effect is usually small.
What this interaction means in plain words
Haloperidol and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and beta-adrenergic cardiovascular effects.
What to do
Monitor for palpitations and arrhythmia, and obtain an ECG in patients with other QT risk factors. Correct hypokalemia, which beta-agonists can worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Haloperidol and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can have cardiovascular effects including QT prolongation and tachycardia, which may be additive with haloperidol. Systemic exposure from inhalation is low, so the effect is usually small.
How serious is the interaction between Haloperidol and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmia, and obtain an ECG in patients with other QT risk factors. Correct hypokalemia, which beta-agonists can worsen.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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