Drug interactions
Haloperidol + Yohimbine
Severity: Minor
Haloperidol and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is sedating and blocks dopamine and alpha-adrenergic receptors, whereas yohimbine is an alpha-2 antagonist with stimulant and anxiogenic properties. The net effect on alertness is unpredictable, and yohimbine may also cause blood pressure and heart rate changes that add to haloperidol's alpha-blocking hypotension or arrhythmia risk.
What this interaction means in plain words
Haloperidol and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on CNS arousal and adrenergic tone; no established pharmacokinetic mechanism.
What to do
Monitor blood pressure, heart rate and level of alertness when the two are used together. Reassess the need for yohimbine in patients with psychosis or anxiety, since it may worsen these symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Yohimbine?
MediHelp rates the interaction as minor. Haloperidol and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Haloperidol is sedating and blocks dopamine and alpha-adrenergic receptors, whereas yohimbine is an alpha-2 antagonist with stimulant and anxiogenic properties. The net effect on alertness is unpredictable, and yohimbine may also cause blood pressure and heart rate changes that add to haloperidol's alpha-blocking hypotension or arrhythmia risk.
How serious is the interaction between Haloperidol and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and level of alertness when the two are used together. Reassess the need for yohimbine in patients with psychosis or anxiety, since it may worsen these symptoms.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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