Drug interactions
Henbane + Paliperidone
Severity: Moderate
Henbane and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains the antimuscarinic alkaloids hyoscyamine and scopolamine, which add to paliperidone's anticholinergic effects. Anticholinergic slowing of gut transit might also alter oral absorption, and confusion, constipation and urinary retention can result.
What this interaction means in plain words
Henbane and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects; reduced GI motility may alter absorption of the oral drug.
What to do
Avoid combining where possible, or monitor for anticholinergic toxicity and loss of antipsychotic effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Henbane with Paliperidone?
MediHelp rates the interaction as moderate. Henbane and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains the antimuscarinic alkaloids hyoscyamine and scopolamine, which add to paliperidone's anticholinergic effects. Anticholinergic slowing of gut transit might also alter oral absorption, and confusion, constipation and urinary retention can result.
How serious is the interaction between Henbane and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or monitor for anticholinergic toxicity and loss of antipsychotic effect.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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