Drug interactions
Henbane + Solifenacin
Severity: Major
Henbane and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids that add to solifenacin effects. Toxicity can include delirium, tachycardia, urinary retention and hyperthermia.
What this interaction means in plain words
Henbane and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antimuscarinic effects from the tropane alkaloids in henbane.
What to do
Advise avoiding henbane products while taking solifenacin; assess for anticholinergic toxicity if exposure has occurred.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Henbane with Solifenacin?
MediHelp rates the interaction as major. Henbane and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids that add to solifenacin effects. Toxicity can include delirium, tachycardia, urinary retention and hyperthermia.
How serious is the interaction between Henbane and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding henbane products while taking solifenacin; assess for anticholinergic toxicity if exposure has occurred.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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