Drug interactions
Heparin + Losartan
Severity: Moderate
Heparin and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress aldosterone secretion, and when combined with losartan the risk of hyperkalemia increases. Risk is highest with prolonged heparin use, renal impairment or diabetes.
What this interaction means in plain words
Heparin and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis adds to reduced potassium excretion from angiotensin receptor blockade.
What to do
Monitor serum potassium in patients receiving heparin for more than a few days or with renal impairment or diabetes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Losartan?
MediHelp rates the interaction as moderate. Heparin and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress aldosterone secretion, and when combined with losartan the risk of hyperkalemia increases. Risk is highest with prolonged heparin use, renal impairment or diabetes.
How serious is the interaction between Heparin and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients receiving heparin for more than a few days or with renal impairment or diabetes.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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