Drug interactions
Heparin + Tipranavir
Severity: Moderate
Heparin and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, when boosted with ritonavir, has been associated with bleeding events including intracranial hemorrhage and may impair platelet function. Combined with heparin the bleeding risk may be increased.
What this interaction means in plain words
Heparin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Additive pharmacodynamic effect: tipranavir's antiplatelet activity adds to heparin anticoagulation.
What to do
Monitor for bleeding and follow aPTT/anti-Xa and hemoglobin as clinically indicated. Avoid other bleeding-risk drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Heparin with Tipranavir?
MediHelp rates the interaction as moderate. Heparin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, when boosted with ritonavir, has been associated with bleeding events including intracranial hemorrhage and may impair platelet function. Combined with heparin the bleeding risk may be increased.
How serious is the interaction between Heparin and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and follow aPTT/anti-Xa and hemoglobin as clinically indicated. Avoid other bleeding-risk drugs where possible.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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