Drug interactions
Hepatitis a / b vaccine + Mycophenolate mofetil
Severity: Moderate
Hepatitis a / b vaccine and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate suppresses lymphocyte proliferation and can blunt antibody responses to inactivated vaccines. The combined hepatitis A/B vaccine may give lower or shorter-lived protection in treated patients. The vaccine is not a live product, so the concern is reduced efficacy rather than infection.
What this interaction means in plain words
Hepatitis a / b vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of inosine monophosphate dehydrogenase limits T and B lymphocyte proliferation, impairing the immune response to vaccination.
What to do
Vaccinate before starting mycophenolate when feasible, and otherwise still give the vaccine. Check anti-HBs titres after the series and revaccinate or give a higher dose if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Hepatitis a / b vaccine with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate suppresses lymphocyte proliferation and can blunt antibody responses to inactivated vaccines. The combined hepatitis A/B vaccine may give lower or shorter-lived protection in treated patients. The vaccine is not a live product, so the concern is reduced efficacy rather than infection.
How serious is the interaction between Hepatitis a / b vaccine and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting mycophenolate when feasible, and otherwise still give the vaccine. Check anti-HBs titres after the series and revaccinate or give a higher dose if the response is inadequate.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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