Drug interactions
Hepatitis a / b vaccine + Tacrolimus
Severity: Moderate
Hepatitis a / b vaccine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can lower seroconversion and antibody titers after this inactivated vaccine. Protection may be inadequate with standard dosing.
What this interaction means in plain words
Hepatitis a / b vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell-dependent vaccine responses.
What to do
Vaccinate before transplantation where possible and check anti-HBs and anti-HAV titers afterward. Revaccinate or boost if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Hepatitis a / b vaccine with Tacrolimus?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can lower seroconversion and antibody titers after this inactivated vaccine. Protection may be inadequate with standard dosing.
How serious is the interaction between Hepatitis a / b vaccine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before transplantation where possible and check anti-HBs and anti-HAV titers afterward. Revaccinate or boost if the response is inadequate.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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