Drug interactions
Hepatitis a / typhoid vaccine + Mycophenolate mofetil
Severity: Moderate
Hepatitis a / typhoid vaccine and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate may reduce the antibody response to inactivated hepatitis A and typhoid polysaccharide vaccines. Protection may be incomplete in transplant or autoimmune patients. Because the vaccine is inactivated, it does not cause vaccine-strain infection.
What this interaction means in plain words
Hepatitis a / typhoid vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mycophenolate inhibits lymphocyte proliferation through IMPDH inhibition, weakening humoral responses to vaccines.
What to do
Give the vaccine at least 2 weeks before immunosuppression when possible. Consider checking hepatitis A antibody and maintain food and water precautions when travelling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Hepatitis a / typhoid vaccine with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Hepatitis a / typhoid vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate may reduce the antibody response to inactivated hepatitis A and typhoid polysaccharide vaccines. Protection may be incomplete in transplant or autoimmune patients. Because the vaccine is inactivated, it does not cause vaccine-strain infection.
How serious is the interaction between Hepatitis a / typhoid vaccine and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 2 weeks before immunosuppression when possible. Consider checking hepatitis A antibody and maintain food and water precautions when travelling.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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