Drug interactions
Hepatitis a / typhoid vaccine + Sirolimus
Severity: Moderate
Hepatitis a / typhoid vaccine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may reduce the immune response to this combined inactivated vaccine, leaving the patient incompletely protected. The parenteral vaccine does not cause infection.
What this interaction means in plain words
Hepatitis a / typhoid vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sirolimus immunosuppression impairs vaccine-induced antibody production.
What to do
Vaccinate before starting sirolimus when feasible, and avoid the oral live typhoid vaccine. Consider checking hepatitis A antibody after vaccination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Hepatitis a / typhoid vaccine with Sirolimus?
MediHelp rates the interaction as moderate. Hepatitis a / typhoid vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may reduce the immune response to this combined inactivated vaccine, leaving the patient incompletely protected. The parenteral vaccine does not cause infection.
How serious is the interaction between Hepatitis a / typhoid vaccine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting sirolimus when feasible, and avoid the oral live typhoid vaccine. Consider checking hepatitis A antibody after vaccination.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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