Drug interactions
Hepatitis A vaccine inactivated + Oxaliplatin
Severity: Moderate
Hepatitis A vaccine inactivated and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy-induced immunosuppression can blunt the antibody response to inactivated hepatitis A vaccine. The vaccine is not harmful, but protection may be inadequate.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis A vaccine inactivated belongs to Anti Virals; Oxaliplatin belongs to Oncology.
Why it happens
Myelosuppressive chemotherapy impairs immune responses to vaccine antigens.
What to do
Where possible vaccinate at least 2 weeks before starting chemotherapy. If given during therapy, consider checking antibody response or revaccinating after immune recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Oxaliplatin?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy-induced immunosuppression can blunt the antibody response to inactivated hepatitis A vaccine. The vaccine is not harmful, but protection may be inadequate.
How serious is the interaction between Hepatitis A vaccine inactivated and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible vaccinate at least 2 weeks before starting chemotherapy. If given during therapy, consider checking antibody response or revaccinating after immune recovery.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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