Drug interactions
Hepatitis A vaccine inactivated + Teplizumab
Severity: Moderate
Hepatitis A vaccine inactivated and Teplizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teplizumab causes transient lymphocyte depletion and immune modulation that may reduce the response to inactivated vaccines. There is no infection risk from the vaccine itself, but protection may be inadequate.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Teplizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis A vaccine inactivated belongs to Anti Virals; Teplizumab belongs to Miscellaneous.
Why it happens
Pharmacodynamic: anti-CD3 mediated immune modulation blunts vaccine antibody responses.
What to do
Give age-appropriate vaccines before starting teplizumab. Avoid inactivated vaccines within 2 weeks before, during, and for 6 weeks after treatment, and consider checking antibody titers if vaccinated outside this window.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Other interactions of Teplizumab
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Teplizumab?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Teplizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teplizumab causes transient lymphocyte depletion and immune modulation that may reduce the response to inactivated vaccines. There is no infection risk from the vaccine itself, but protection may be inadequate.
How serious is the interaction between Hepatitis A vaccine inactivated and Teplizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give age-appropriate vaccines before starting teplizumab. Avoid inactivated vaccines within 2 weeks before, during, and for 6 weeks after treatment, and consider checking antibody titers if vaccinated outside this window.
What other medicines interact with Hepatitis A vaccine inactivated?
MediHelp also lists interactions of Hepatitis A vaccine inactivated with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Hepatitis A vaccine inactivated page.
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