Drug interactions
Measles mumps and rubella vaccine + Teplizumab
Severity: Major
Measles mumps and rubella vaccine and Teplizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teplizumab is an anti-CD3 antibody that causes transient lymphocyte depletion and immune modulation. A live attenuated vaccine given around this time may cause vaccine-strain infection and may produce an inadequate immune response.
What this interaction means in plain words
Measles mumps and rubella vaccine and Teplizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Measles mumps and rubella vaccine belongs to Miscellaneous; Teplizumab belongs to Miscellaneous.
Why it happens
Pharmacodynamic: T-cell directed immunomodulation reduces the ability to control live vaccine viruses and impairs vaccine response.
What to do
Complete age-appropriate vaccinations before starting teplizumab. Avoid live vaccines within 8 weeks before treatment, during treatment, and for up to 52 weeks after treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Teplizumab
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Teplizumab?
MediHelp rates the interaction as major. Measles mumps and rubella vaccine and Teplizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Teplizumab is an anti-CD3 antibody that causes transient lymphocyte depletion and immune modulation. A live attenuated vaccine given around this time may cause vaccine-strain infection and may produce an inadequate immune response.
How serious is the interaction between Measles mumps and rubella vaccine and Teplizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete age-appropriate vaccinations before starting teplizumab. Avoid live vaccines within 8 weeks before treatment, during treatment, and for up to 52 weeks after treatment.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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