Drug interactions
Human papillomavirus vaccine + Teplizumab
Severity: Moderate
Human papillomavirus vaccine and Teplizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teplizumab is an anti-CD3 antibody causing transient lymphocyte depletion and immune modulation, which may impair vaccine responses. Labeling advises against inactivated vaccines around the treatment period.
What this interaction means in plain words
Human papillomavirus vaccine and Teplizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Human papillomavirus vaccine belongs to Miscellaneous; Teplizumab belongs to Miscellaneous.
Why it happens
Anti-CD3-mediated T-cell modulation may reduce immune response to vaccines.
What to do
Complete age-appropriate vaccinations before starting teplizumab. Avoid inactivated vaccines within 2 weeks before, during, and for 6 weeks after treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Teplizumab
Frequently asked questions
Can I take Human papillomavirus vaccine with Teplizumab?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Teplizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teplizumab is an anti-CD3 antibody causing transient lymphocyte depletion and immune modulation, which may impair vaccine responses. Labeling advises against inactivated vaccines around the treatment period.
How serious is the interaction between Human papillomavirus vaccine and Teplizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete age-appropriate vaccinations before starting teplizumab. Avoid inactivated vaccines within 2 weeks before, during, and for 6 weeks after treatment.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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