Drug interactions
Pneumococcal vaccine 13-valent + Teplizumab
Severity: Moderate
Pneumococcal vaccine 13-valent and Teplizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teplizumab is an anti-CD3 antibody that causes transient lymphocyte depletion and immune modulation, which may reduce vaccine immune responses. Labeling advises against giving inactivated vaccines close to treatment.
What this interaction means in plain words
Pneumococcal vaccine 13-valent and Teplizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pneumococcal vaccine 13-valent belongs to Miscellaneous; Teplizumab belongs to Miscellaneous.
Why it happens
Anti-CD3 mediated T-cell modulation and lymphopenia may impair vaccine immune response.
What to do
Complete age-appropriate vaccinations before teplizumab. Avoid inactivated vaccines from 2 weeks before until 6 weeks after treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Other interactions of Teplizumab
Frequently asked questions
Can I take Pneumococcal vaccine 13-valent with Teplizumab?
MediHelp rates the interaction as moderate. Pneumococcal vaccine 13-valent and Teplizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teplizumab is an anti-CD3 antibody that causes transient lymphocyte depletion and immune modulation, which may reduce vaccine immune responses. Labeling advises against giving inactivated vaccines close to treatment.
How serious is the interaction between Pneumococcal vaccine 13-valent and Teplizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete age-appropriate vaccinations before teplizumab. Avoid inactivated vaccines from 2 weeks before until 6 weeks after treatment.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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