Drug interactions
Hepatitis b immune globulin + Smallpox vaccine live
Severity: Minor
Hepatitis b immune globulin and Smallpox vaccine live: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passive antibodies from HBIG could in theory reduce replication of vaccinia virus and weaken the vaccine response. HBIG has little specific vaccinia activity, so the practical effect is likely small.
What this interaction means in plain words
Hepatitis b immune globulin and Smallpox vaccine live have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical neutralization of live vaccine virus by passively acquired antibody.
What to do
No routine delay is generally needed. Confirm vaccine take (primary lesion) and revaccinate if there is no take.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hepatitis b immune globulin and Smallpox vaccine live, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hepatitis b immune globulin
- Efgartigimod / hyaluronidase sc + Hepatitis b immune globulin Moderate
- Efgartigimod alfa + Hepatitis b immune globulin Moderate
- Hepatitis b immune globulin + Measles mumps and rubella vaccine Moderate
- Hepatitis b immune globulin + Measles mumps and rubella vaccine live Moderate
- Hepatitis b immune globulin + Measles mumps rubella and varicella vaccine live Moderate
- Hepatitis b immune globulin + Measles vaccine Moderate
Frequently asked questions
Can I take Hepatitis b immune globulin with Smallpox vaccine live?
MediHelp rates the interaction as minor. Hepatitis b immune globulin and Smallpox vaccine live have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Passive antibodies from HBIG could in theory reduce replication of vaccinia virus and weaken the vaccine response. HBIG has little specific vaccinia activity, so the practical effect is likely small.
How serious is the interaction between Hepatitis b immune globulin and Smallpox vaccine live?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine delay is generally needed. Confirm vaccine take (primary lesion) and revaccinate if there is no take.
What other medicines interact with Hepatitis b immune globulin?
MediHelp also lists interactions of Hepatitis b immune globulin with, for example, Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Measles mumps and rubella vaccine. The full list is on the Hepatitis b immune globulin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
