Drug interactions
Hepatitis b vaccine + Mycophenolate mofetil
Severity: Moderate
Hepatitis b vaccine and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patients taking mycophenolate often mount a weaker antibody response to hepatitis B vaccine, and seroconversion rates are lower in transplant recipients. This leaves some patients unprotected despite completing the standard series.
What this interaction means in plain words
Hepatitis b vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
IMPDH inhibition reduces B and T lymphocyte proliferation, decreasing antibody production after vaccination.
What to do
Vaccinate early, before immunosuppression if possible, and use a higher-dose or adjuvanted schedule where recommended. Measure anti-HBs 1 to 2 months after the series and revaccinate non-responders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Hepatitis b vaccine with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Hepatitis b vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients taking mycophenolate often mount a weaker antibody response to hepatitis B vaccine, and seroconversion rates are lower in transplant recipients. This leaves some patients unprotected despite completing the standard series.
How serious is the interaction between Hepatitis b vaccine and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate early, before immunosuppression if possible, and use a higher-dose or adjuvanted schedule where recommended. Measure anti-HBs 1 to 2 months after the series and revaccinate non-responders.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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