Drug interactions
Hepatitis b vaccine + Oxaliplatin
Severity: Moderate
Hepatitis b vaccine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin-related immunosuppression may lower the antibody response to hepatitis B vaccine, so seroprotection may not be achieved.
What this interaction means in plain words
Hepatitis b vaccine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate at least 2 weeks before chemotherapy where feasible. Check anti-HBs titer and revaccinate if needed after therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Hepatitis b vaccine with Oxaliplatin?
MediHelp rates the interaction as moderate. Hepatitis b vaccine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin-related immunosuppression may lower the antibody response to hepatitis B vaccine, so seroprotection may not be achieved.
How serious is the interaction between Hepatitis b vaccine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before chemotherapy where feasible. Check anti-HBs titer and revaccinate if needed after therapy.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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