Drug interactions
Hepatitis b vaccine + Tacrolimus
Severity: Moderate
Hepatitis b vaccine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transplant recipients on tacrolimus often respond poorly to hepatitis B vaccine, with lower antibody titers. Protection may be inadequate with standard dosing.
What this interaction means in plain words
Hepatitis b vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell-dependent vaccine responses.
What to do
Vaccinate early and consider higher-dose or adjuvanted regimens. Check anti-HBs after the series and boost if titers are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Hepatitis b vaccine with Tacrolimus?
MediHelp rates the interaction as moderate. Hepatitis b vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transplant recipients on tacrolimus often respond poorly to hepatitis B vaccine, with lower antibody titers. Protection may be inadequate with standard dosing.
How serious is the interaction between Hepatitis b vaccine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate early and consider higher-dose or adjuvanted regimens. Check anti-HBs after the series and boost if titers are low.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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