Drug interactions
Histrelin + Isoflurane
Severity: Moderate
Histrelin and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin is a GnRH agonist, and androgen deprivation therapy of this class can prolong the QT interval. Isoflurane may add to this effect, though the clinical risk is modest.
What this interaction means in plain words
Histrelin and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Isoflurane belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization; GnRH agonists may lengthen the QT interval through androgen suppression.
What to do
Review baseline ECG and electrolytes before anesthesia in patients with other QT risk factors. Monitor the QTc perioperatively when other risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Histrelin and Isoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Isoflurane
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Isoflurane?
MediHelp rates the interaction as moderate. Histrelin and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin is a GnRH agonist, and androgen deprivation therapy of this class can prolong the QT interval. Isoflurane may add to this effect, though the clinical risk is modest.
How serious is the interaction between Histrelin and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline ECG and electrolytes before anesthesia in patients with other QT risk factors. Monitor the QTc perioperatively when other risk factors are present.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
