Drug interactions
Histrelin + Metformin-repaglinide
Severity: Minor
Histrelin and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
GnRH agonists such as histrelin can reduce insulin sensitivity and worsen glycemic control, particularly with prolonged use through androgen or estrogen suppression. This may weaken the effect of metformin and repaglinide. The change is generally gradual.
What this interaction means in plain words
Histrelin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Histrelin belongs to Musculoskeletal; Metformin-repaglinide belongs to Endocrine.
Why it happens
Sex-hormone suppression leads to reduced insulin sensitivity, opposing antidiabetic effect.
What to do
Monitor blood glucose and HbA1c during long-term histrelin therapy and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Metformin-repaglinide?
MediHelp rates the interaction as minor. Histrelin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. GnRH agonists such as histrelin can reduce insulin sensitivity and worsen glycemic control, particularly with prolonged use through androgen or estrogen suppression. This may weaken the effect of metformin and repaglinide. The change is generally gradual.
How serious is the interaction between Histrelin and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during long-term histrelin therapy and adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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