Drug interactions
Histrelin + Methadone
Severity: Moderate
Histrelin and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin is a GnRH agonist, and androgen deprivation therapy may prolong the QT interval. Combined with methadone, this may add to the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Histrelin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation, with methadone blocking the hERG channel and androgen suppression altering cardiac repolarization.
What to do
Check a baseline ECG and electrolytes, and repeat the ECG after treatment changes. Correct potassium and magnesium and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Methadone?
MediHelp rates the interaction as moderate. Histrelin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin is a GnRH agonist, and androgen deprivation therapy may prolong the QT interval. Combined with methadone, this may add to the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Histrelin and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and repeat the ECG after treatment changes. Correct potassium and magnesium and avoid adding other QT-prolonging drugs.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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