Drug interactions
Histrelin + Nilotinib
Severity: Moderate
Histrelin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, as a GnRH agonist, produces androgen deprivation that can prolong the QT interval, and nilotinib has the same effect. Combined use may increase the risk of torsades de pointes.
What this interaction means in plain words
Histrelin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Nilotinib belongs to Oncology.
Why it happens
Additive QT prolongation, with GnRH agonist-induced androgen deprivation lengthening repolarization.
What to do
Obtain a baseline ECG and electrolytes and repeat periodically during combined use. Consider an alternative if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Nilotinib?
MediHelp rates the interaction as moderate. Histrelin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, as a GnRH agonist, produces androgen deprivation that can prolong the QT interval, and nilotinib has the same effect. Combined use may increase the risk of torsades de pointes.
How serious is the interaction between Histrelin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and repeat periodically during combined use. Consider an alternative if the patient has other QT risk factors.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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