Drug interactions
Histrelin + Sorafenib
Severity: Moderate
Histrelin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with GnRH agonists such as histrelin can prolong the QT interval. Combined with sorafenib, which also prolongs QT, the risk of torsades de pointes may increase.
What this interaction means in plain words
Histrelin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation, with histrelin acting via androgen suppression.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities. Monitor the QTc periodically during combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Sorafenib?
MediHelp rates the interaction as moderate. Histrelin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with GnRH agonists such as histrelin can prolong the QT interval. Combined with sorafenib, which also prolongs QT, the risk of torsades de pointes may increase.
How serious is the interaction between Histrelin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities. Monitor the QTc periodically during combined therapy.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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