Drug interactions
Homatropine + Succinylcholine
Severity: Minor
Homatropine and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Homatropine is an antimuscarinic that opposes the muscarinic effects of succinylcholine, such as bradycardia and increased secretions. It has little effect on neuromuscular blockade. Systemic exposure is generally low with ophthalmic use.
What this interaction means in plain words
Homatropine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Homatropine belongs to Genitourinary; Succinylcholine belongs to Musculoskeletal.
Why it happens
Muscarinic receptor blockade counteracts the muscarinic effects of succinylcholine, with no important effect on nicotinic transmission.
What to do
No dose change is needed. Monitor heart rate during anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Homatropine and Succinylcholine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Succinylcholine
Other interactions of Homatropine
- Amantadine + Homatropine Moderate
- Amitriptyline + Homatropine Moderate
- Atropine + Homatropine Moderate
- Benztropine + Homatropine Moderate
- Bethanechol + Homatropine Moderate
- Chlorpromazine + Homatropine Moderate
Frequently asked questions
Can I take Homatropine with Succinylcholine?
MediHelp rates the interaction as minor. Homatropine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Homatropine is an antimuscarinic that opposes the muscarinic effects of succinylcholine, such as bradycardia and increased secretions. It has little effect on neuromuscular blockade. Systemic exposure is generally low with ophthalmic use.
How serious is the interaction between Homatropine and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor heart rate during anesthesia.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
