Drug interactions
Horse chestnut seed + Piroxicam
Severity: Minor
Horse chestnut seed and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut contains aescin and coumarin-type compounds that may have anticoagulant effects, theoretically increasing bleeding with piroxicam. Clinical evidence is scant.
What this interaction means in plain words
Horse chestnut seed and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak anticoagulant or antiplatelet effect adding to NSAID platelet inhibition.
What to do
Advise patients to report bleeding or bruising; avoid the supplement if other bleeding risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Horse chestnut seed and Piroxicam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Horse chestnut seed with Piroxicam?
MediHelp rates the interaction as minor. Horse chestnut seed and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Horse chestnut contains aescin and coumarin-type compounds that may have anticoagulant effects, theoretically increasing bleeding with piroxicam. Clinical evidence is scant.
How serious is the interaction between Horse chestnut seed and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report bleeding or bruising; avoid the supplement if other bleeding risk factors are present.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
