Drug interactions
Horse chestnut seed + Vitamin k1
Severity: Minor
Horse chestnut seed and Vitamin k1: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut seed contains aescin and esculin-type coumarin compounds that may have antithrombotic effects, theoretically opposing phytonadione. Clinical data are limited.
What this interaction means in plain words
Horse chestnut seed and Vitamin k1 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Coumarin-like constituents and aescin may reduce coagulation, pharmacodynamically opposing phytonadione.
What to do
Avoid horse chestnut in patients receiving phytonadione for bleeding or coagulopathy; monitor INR if used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin k1
- Vitamin k1 + Warfarin Major
- Cholestyramine + Vitamin k1 Moderate
- Colestipol + Vitamin k1 Moderate
- Ketorolac intranasal + Vitamin k1 Moderate
- Mineral oil + Vitamin k1 Moderate
- Orlistat + Vitamin k1 Moderate
Frequently asked questions
Can I take Horse chestnut seed with Vitamin k1?
MediHelp rates the interaction as minor. Horse chestnut seed and Vitamin k1 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Horse chestnut seed contains aescin and esculin-type coumarin compounds that may have antithrombotic effects, theoretically opposing phytonadione. Clinical data are limited.
How serious is the interaction between Horse chestnut seed and Vitamin k1?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid horse chestnut in patients receiving phytonadione for bleeding or coagulopathy; monitor INR if used.
What other medicines interact with Vitamin k1?
MediHelp also lists interactions of Vitamin k1 with, for example, Warfarin, Cholestyramine, Colestipol. The full list is on the Vitamin k1 page.
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