Drug interactions
Colestipol + Vitamin k1
Severity: Moderate
Colestipol and Vitamin k1: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol is a bile acid sequestrant that impairs absorption of fat-soluble vitamins, including vitamin K. Prolonged use may lower vitamin K status and, in susceptible patients, contribute to prolonged clotting times or bleeding.
What this interaction means in plain words
Colestipol and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Vitamin k1 belongs to Cardiovascular.
Why it happens
Colestipol binds bile acids in the gut, reducing micelle formation and absorption of oral vitamin K.
What to do
Give oral vitamin K at least 4 hours before or after colestipol. Monitor INR or prothrombin time in patients on long-term colestipol or with other risk factors for deficiency.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin k1
- Vitamin k1 + Warfarin Major
- Cholestyramine + Vitamin k1 Moderate
- Ketorolac intranasal + Vitamin k1 Moderate
- Mineral oil + Vitamin k1 Moderate
- Orlistat + Vitamin k1 Moderate
- Aescin + Vitamin k1 Minor
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Vitamin k1?
MediHelp rates the interaction as moderate. Colestipol and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is a bile acid sequestrant that impairs absorption of fat-soluble vitamins, including vitamin K. Prolonged use may lower vitamin K status and, in susceptible patients, contribute to prolonged clotting times or bleeding.
How serious is the interaction between Colestipol and Vitamin k1?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral vitamin K at least 4 hours before or after colestipol. Monitor INR or prothrombin time in patients on long-term colestipol or with other risk factors for deficiency.
What other medicines interact with Vitamin k1?
MediHelp also lists interactions of Vitamin k1 with, for example, Warfarin, Cholestyramine, Ketorolac intranasal. The full list is on the Vitamin k1 page.
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