Drug interactions
Orlistat + Vitamin k1
Severity: Moderate
Orlistat and Vitamin k1: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat decreases absorption of fat-soluble vitamins including vitamin K, and reduced vitamin K status may occur with prolonged use. This matters most for patients taking warfarin, in whom INR may rise.
What this interaction means in plain words
Orlistat and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orlistat belongs to Miscellaneous; Vitamin k1 belongs to Cardiovascular.
Why it happens
Inhibition of gastrointestinal lipase reduces absorption of fat-soluble vitamins.
What to do
Take vitamin K-containing supplements at least 2 hours apart from orlistat. Monitor INR in patients on vitamin K antagonists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Other interactions of Vitamin k1
- Vitamin k1 + Warfarin Major
- Cholestyramine + Vitamin k1 Moderate
- Colestipol + Vitamin k1 Moderate
- Ketorolac intranasal + Vitamin k1 Moderate
- Mineral oil + Vitamin k1 Moderate
- Aescin + Vitamin k1 Minor
Frequently asked questions
Can I take Orlistat with Vitamin k1?
MediHelp rates the interaction as moderate. Orlistat and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat decreases absorption of fat-soluble vitamins including vitamin K, and reduced vitamin K status may occur with prolonged use. This matters most for patients taking warfarin, in whom INR may rise.
How serious is the interaction between Orlistat and Vitamin k1?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vitamin K-containing supplements at least 2 hours apart from orlistat. Monitor INR in patients on vitamin K antagonists.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporine, Cyclosporin, Triheptanoin. The full list is on the Orlistat page.
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