Drug interactions
Human papillomavirus vaccine nonavalent + Tacrolimus
Severity: Moderate
Human papillomavirus vaccine nonavalent and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic immunosuppression with tacrolimus can blunt the antibody response to the nonavalent HPV vaccine, so protection may be lower or shorter lived. The vaccine is not live and is not unsafe in transplant recipients, but its effectiveness may be reduced.
What this interaction means in plain words
Human papillomavirus vaccine nonavalent and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell activation and thereby weakens the humoral response to vaccination.
What to do
Do not withhold the vaccine; ideally complete the series before transplantation or when immunosuppression is at its lowest. Follow the full recommended schedule and consider whether further doses or serologic assessment are appropriate per local guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine nonavalent with Tacrolimus?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine nonavalent and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic immunosuppression with tacrolimus can blunt the antibody response to the nonavalent HPV vaccine, so protection may be lower or shorter lived. The vaccine is not live and is not unsafe in transplant recipients, but its effectiveness may be reduced.
How serious is the interaction between Human papillomavirus vaccine nonavalent and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold the vaccine; ideally complete the series before transplantation or when immunosuppression is at its lowest. Follow the full recommended schedule and consider whether further doses or serologic assessment are appropriate per local guidance.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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