Drug interactions
Human papillomavirus vaccine quadrivalent + Sirolimus
Severity: Moderate
Human papillomavirus vaccine quadrivalent and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression with sirolimus may blunt the antibody response to this inactivated recombinant vaccine, leaving patients less protected. The vaccine is not live and is not harmful in itself.
What this interaction means in plain words
Human papillomavirus vaccine quadrivalent and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: mTOR inhibition suppresses lymphocyte proliferation and the vaccine immune response.
What to do
Vaccination is still recommended and should not be withheld; ideally complete it before starting immunosuppression. Consider checking the response where relevant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine quadrivalent with Sirolimus?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine quadrivalent and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression with sirolimus may blunt the antibody response to this inactivated recombinant vaccine, leaving patients less protected. The vaccine is not live and is not harmful in itself.
How serious is the interaction between Human papillomavirus vaccine quadrivalent and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination is still recommended and should not be withheld; ideally complete it before starting immunosuppression. Consider checking the response where relevant.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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