Drug interactions
Human papillomavirus vaccine quadrivalent + Tacrolimus
Severity: Moderate
Human papillomavirus vaccine quadrivalent and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus-related immunosuppression can reduce the antibody response to the quadrivalent HPV vaccine, which may leave protection incomplete. The vaccine is non-live and can be given safely, but its benefit may be diminished.
What this interaction means in plain words
Human papillomavirus vaccine quadrivalent and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell activation and thereby weakens the humoral response to vaccination.
What to do
Vaccinate on schedule rather than avoiding the vaccine, preferably before transplantation or during the lowest period of immunosuppression. Complete the full series and consider serologic follow-up where guidelines recommend it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine quadrivalent with Tacrolimus?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine quadrivalent and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus-related immunosuppression can reduce the antibody response to the quadrivalent HPV vaccine, which may leave protection incomplete. The vaccine is non-live and can be given safely, but its benefit may be diminished.
How serious is the interaction between Human papillomavirus vaccine quadrivalent and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate on schedule rather than avoiding the vaccine, preferably before transplantation or during the lowest period of immunosuppression. Complete the full series and consider serologic follow-up where guidelines recommend it.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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