Drug interactions
Hydralazine + Isoproterenol
Severity: Moderate
Hydralazine and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol is a beta agonist that increases heart rate and contractility, which adds to hydralazine-induced reflex tachycardia. Its vasodilating action may also add to hypotension, so the effect on blood pressure is unpredictable.
What this interaction means in plain words
Hydralazine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Overlapping pharmacodynamic cardiovascular effects of beta-adrenergic stimulation and direct arterial vasodilation.
What to do
Monitor heart rate, blood pressure and ECG, especially in patients with coronary disease. Adjust doses to hemodynamic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Isoproterenol
Frequently asked questions
Can I take Hydralazine with Isoproterenol?
MediHelp rates the interaction as moderate. Hydralazine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol is a beta agonist that increases heart rate and contractility, which adds to hydralazine-induced reflex tachycardia. Its vasodilating action may also add to hypotension, so the effect on blood pressure is unpredictable.
How serious is the interaction between Hydralazine and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, especially in patients with coronary disease. Adjust doses to hemodynamic response.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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