Drug interactions
Hydralazine + Ketoprofen
Severity: Moderate
Hydralazine and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure-lowering effect of hydralazine. Loss of blood pressure control may occur, particularly with sustained NSAID use.
What this interaction means in plain words
Hydralazine and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit vasodilatory prostaglandin synthesis and promote sodium and fluid retention, opposing vasodilator action.
What to do
Monitor blood pressure when ketoprofen is started or continued and adjust antihypertensive therapy if needed. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Ketoprofen?
MediHelp rates the interaction as moderate. Hydralazine and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood pressure-lowering effect of hydralazine. Loss of blood pressure control may occur, particularly with sustained NSAID use.
How serious is the interaction between Hydralazine and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ketoprofen is started or continued and adjust antihypertensive therapy if needed. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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