Drug interactions
Hydralazine + Linezolid
Severity: Minor
Hydralazine and Linezolid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid's MAO inhibition can cause pressor responses, which would oppose the antihypertensive effect of hydralazine, and reflex sympathetic activation may make blood pressure changes less predictable. The interaction is largely theoretical.
What this interaction means in plain words
Hydralazine and Linezolid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydralazine belongs to Cardiovascular; Linezolid belongs to Anti Bacterial.
Why it happens
Pressor effects from MAO inhibition by linezolid oppose the vasodilation produced by hydralazine.
What to do
Monitor blood pressure during linezolid therapy and adjust antihypertensive dosing if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Linezolid?
MediHelp rates the interaction as minor. Hydralazine and Linezolid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Linezolid's MAO inhibition can cause pressor responses, which would oppose the antihypertensive effect of hydralazine, and reflex sympathetic activation may make blood pressure changes less predictable. The interaction is largely theoretical.
How serious is the interaction between Hydralazine and Linezolid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during linezolid therapy and adjust antihypertensive dosing if control is lost.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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