Drug interactions
Hydralazine + Pexidartinib
Severity: Moderate
Hydralazine and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious liver injury, and hydralazine has been associated with rare cases of hepatotoxicity. The combination could add to hepatic risk, though the contribution of hydralazine is small.
What this interaction means in plain words
Hydralazine and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Pexidartinib belongs to Oncology.
Why it happens
Potential additive hepatotoxicity.
What to do
Monitor liver enzymes and bilirubin regularly during combined therapy. Stop the suspected agent if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Pexidartinib
Frequently asked questions
Can I take Hydralazine with Pexidartinib?
MediHelp rates the interaction as moderate. Hydralazine and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib carries a boxed warning for serious liver injury, and hydralazine has been associated with rare cases of hepatotoxicity. The combination could add to hepatic risk, though the contribution of hydralazine is small.
How serious is the interaction between Hydralazine and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin regularly during combined therapy. Stop the suspected agent if liver injury develops.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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