Drug interactions
Hydralazine + Tolfenamic acid
Severity: Moderate
Hydralazine and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of hydralazine, particularly with regular use. Fluid retention may further reduce control of blood pressure.
What this interaction means in plain words
Hydralazine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Inhibition of vasodilatory prostaglandin synthesis with sodium and water retention.
What to do
Monitor blood pressure if the NSAID is used regularly, and use the lowest effective dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Hydralazine with Tolfenamic acid?
MediHelp rates the interaction as moderate. Hydralazine and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of hydralazine, particularly with regular use. Fluid retention may further reduce control of blood pressure.
How serious is the interaction between Hydralazine and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if the NSAID is used regularly, and use the lowest effective dose for the shortest duration.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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