Drug interactions
Hydralazine + Treprostinil
Severity: Moderate
Hydralazine and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a prostacyclin analog with potent vasodilating properties. Combined with hydralazine, additive vasodilation can cause hypotension, flushing, headache and reflex tachycardia. The risk is greatest when starting or titrating treprostinil.
What this interaction means in plain words
Hydralazine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation through prostacyclin receptor agonism and direct arteriolar smooth muscle relaxation.
What to do
Monitor blood pressure and heart rate when starting or titrating either drug. Reduce the dose of the antihypertensive if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydralazine and Treprostinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Treprostinil
Frequently asked questions
Can I take Hydralazine with Treprostinil?
MediHelp rates the interaction as moderate. Hydralazine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a prostacyclin analog with potent vasodilating properties. Combined with hydralazine, additive vasodilation can cause hypotension, flushing, headache and reflex tachycardia. The risk is greatest when starting or titrating treprostinil.
How serious is the interaction between Hydralazine and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating either drug. Reduce the dose of the antihypertensive if symptomatic hypotension occurs.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
