Drug interactions
Albuterol + Hydrochlorothiazide
Severity: Moderate
Albuterol and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, and the effect is additive, particularly with high-dose or nebulized albuterol. Hypokalemia may predispose to arrhythmias, especially in patients with heart disease.
What this interaction means in plain words
Albuterol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced renal potassium loss combined with beta2-mediated intracellular potassium shift.
What to do
Monitor serum potassium in patients on regular or high-dose beta2 agonists. Replace potassium or add a potassium-sparing agent as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Albuterol with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Albuterol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, and the effect is additive, particularly with high-dose or nebulized albuterol. Hypokalemia may predispose to arrhythmias, especially in patients with heart disease.
How serious is the interaction between Albuterol and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on regular or high-dose beta2 agonists. Replace potassium or add a potassium-sparing agent as needed.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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