Drug interactions
Hydrochlorothiazide-lisinopril + Indacaterol inhaled
Severity: Moderate
Hydrochlorothiazide-lisinopril and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a long-acting beta-2 agonist, can lower serum potassium, and thiazides also cause potassium loss. Together they may produce clinically significant hypokalemia and possible ECG changes, especially in patients with hypoxia.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 mediated intracellular potassium shift combined with renal potassium wasting from thiazide.
What to do
Monitor serum potassium periodically, particularly in severe COPD or when other hypokalemic factors exist, and supplement as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a long-acting beta-2 agonist, can lower serum potassium, and thiazides also cause potassium loss. Together they may produce clinically significant hypokalemia and possible ECG changes, especially in patients with hypoxia.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, particularly in severe COPD or when other hypokalemic factors exist, and supplement as needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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