Drug interactions
Hydrochlorothiazide-lisinopril + Indapamide
Severity: Moderate
Hydrochlorothiazide-lisinopril and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two thiazide-type diuretics provides little added benefit and increases the risk of hypokalemia, hyponatremia, hypotension and volume depletion. With the ACE inhibitor there is also a risk of renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Duplicate inhibition of distal tubular sodium chloride reabsorption causes additive natriuresis and potassium loss.
What to do
Avoid therapeutic duplication and use a single thiazide-type agent. If combined, monitor sodium, potassium and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Indapamide
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Indapamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two thiazide-type diuretics provides little added benefit and increases the risk of hypokalemia, hyponatremia, hypotension and volume depletion. With the ACE inhibitor there is also a risk of renal impairment.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication and use a single thiazide-type agent. If combined, monitor sodium, potassium and renal function.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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