Drug interactions
Hydrochlorothiazide-lisinopril + Insulin inhaled
Severity: Moderate
Hydrochlorothiazide-lisinopril and Insulin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of insulin in people with diabetes. Insulin requirements may increase after starting or raising the thiazide dose. Lisinopril may in contrast increase insulin sensitivity and hypoglycemia risk.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides impair glucose tolerance via reduced insulin secretion and sensitivity, partly through hypokalemia.
What to do
Monitor blood glucose when the thiazide is started or adjusted, and titrate insulin dose accordingly. Keep potassium in the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Insulin inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of insulin in people with diabetes. Insulin requirements may increase after starting or raising the thiazide dose. Lisinopril may in contrast increase insulin sensitivity and hypoglycemia risk.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Insulin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the thiazide is started or adjusted, and titrate insulin dose accordingly. Keep potassium in the normal range.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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