Drug interactions
Hydrochlorothiazide-lisinopril + Insulin regular human
Severity: Moderate
Hydrochlorothiazide-lisinopril and Insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effect of insulin, so glycemic control may worsen. Lisinopril may in contrast enhance insulin sensitivity and occasionally increase hypoglycemia risk.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia and impaired insulin secretion and sensitivity oppose insulin action, while ACE inhibitors may increase insulin sensitivity.
What to do
Monitor blood glucose when starting or changing the combination and adjust the insulin dose as needed. Check potassium, as correcting hypokalemia helps glucose control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Insulin regular human?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and reduce the effect of insulin, so glycemic control may worsen. Lisinopril may in contrast enhance insulin sensitivity and occasionally increase hypoglycemia risk.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the combination and adjust the insulin dose as needed. Check potassium, as correcting hypokalemia helps glucose control.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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