Drug interactions
Hydrochlorothiazide-lisinopril + Juniper
Severity: Moderate
Hydrochlorothiazide-lisinopril and Juniper: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Juniper has traditional diuretic activity and may add to the fluid and electrolyte loss produced by a thiazide. High doses or prolonged use have been associated with kidney irritation, which is undesirable in patients also taking an ACE inhibitor. Evidence is limited.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Juniper can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive diuretic effect from juniper volatile oils; the mechanism is not well characterized.
What to do
Advise against regular juniper supplements. If used, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Juniper?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Juniper can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Juniper has traditional diuretic activity and may add to the fluid and electrolyte loss produced by a thiazide. High doses or prolonged use have been associated with kidney irritation, which is undesirable in patients also taking an ACE inhibitor. Evidence is limited.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Juniper?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against regular juniper supplements. If used, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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