Drug interactions
Hydrochlorothiazide-lisinopril + Lily of the valley
Severity: Major
Hydrochlorothiazide-lisinopril and Lily of the valley: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley contains cardiac glycosides, and thiazide-induced hypokalemia and hypomagnesemia increase the risk of glycoside toxicity and arrhythmias. Poorly standardized herbal products make toxicity hard to predict.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Lily of the valley can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Thiazide-related potassium and magnesium depletion sensitizes the myocardium to cardiac glycosides.
What to do
Avoid use of lily of the valley preparations. If exposure occurs, check potassium, magnesium and ECG and correct any deficits.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Lily of the valley?
MediHelp rates the interaction as major. Hydrochlorothiazide-lisinopril and Lily of the valley can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lily of the valley contains cardiac glycosides, and thiazide-induced hypokalemia and hypomagnesemia increase the risk of glycoside toxicity and arrhythmias. Poorly standardized herbal products make toxicity hard to predict.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Lily of the valley?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use of lily of the valley preparations. If exposure occurs, check potassium, magnesium and ECG and correct any deficits.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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