Drug interactions
Hydrochlorothiazide-lisinopril + Magnesium sulfate
Severity: Minor
Hydrochlorothiazide-lisinopril and Magnesium sulfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide increases urinary magnesium loss and can cause hypomagnesemia with long-term use, which may offset magnesium therapy. The effect is usually modest and manageable.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides increase renal magnesium excretion.
What to do
Monitor serum magnesium in long-term therapy and adjust the magnesium dose if levels stay low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Magnesium sulfate?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide increases urinary magnesium loss and can cause hypomagnesemia with long-term use, which may offset magnesium therapy. The effect is usually modest and manageable.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Magnesium sulfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium in long-term therapy and adjust the magnesium dose if levels stay low.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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