Drug interactions
Hydrochlorothiazide-lisinopril + Meclofenamate
Severity: Moderate
Hydrochlorothiazide-lisinopril and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can reduce the antihypertensive and diuretic effects of thiazides and ACE inhibitors. The three-drug combination of NSAID, diuretic and ACE inhibitor raises the risk of acute kidney injury and hyperkalemia, especially with dehydration or existing renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduces renal perfusion, opposing diuretic and ACE inhibitor effects.
What to do
Use the lowest effective NSAID dose for the shortest time and maintain hydration. Monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Meclofenamate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can reduce the antihypertensive and diuretic effects of thiazides and ACE inhibitors. The three-drug combination of NSAID, diuretic and ACE inhibitor raises the risk of acute kidney injury and hyperkalemia, especially with dehydration or existing renal impairment.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and maintain hydration. Monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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