Drug interactions
Hydrochlorothiazide-lisinopril + Metformin
Severity: Moderate
Hydrochlorothiazide-lisinopril and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose, particularly at higher doses, and so may weaken glycemic control with metformin. Diuretic-related volume depletion or reduced kidney function may also increase metformin accumulation, and ACE inhibitors may alter glucose handling.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Thiazides cause pharmacodynamic hyperglycemia and may reduce renal clearance of metformin via volume depletion or competition for tubular secretion.
What to do
Monitor blood glucose and HbA1c and adjust antidiabetic therapy if needed; check renal function periodically and ensure hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Metformin
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Metformin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise blood glucose, particularly at higher doses, and so may weaken glycemic control with metformin. Diuretic-related volume depletion or reduced kidney function may also increase metformin accumulation, and ACE inhibitors may alter glucose handling.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and adjust antidiabetic therapy if needed; check renal function periodically and ensure hydration.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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